An anthelmintic
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Milbemycin A3 oxime

Item No. 27967

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-demethoxy-28-deoxy-6R,28-epoxy-5-(hydroxyimino)-25R-methyl-milbemycin B
CAS Number
114177-14-9
Molecular Formula
C31H43NO7
Formula Weight
541.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
245 nm
SMILES
C[C@H]([C@@H](C)CC1)O[C@]21C[C@](OC([C@@]3([H])[C@@]4(O)[C@@]5([H])/C(C(C)=C3)=N/O)=O)([H])C[C@](C/C=C(C)/C[C@@H](C)/C=C/C=C4\CO5)([H])O2
InChi Code
InChI=1S/C31H43NO7/c1-18-7-6-8-23-17-36-28-27(32-35)21(4)14-26(31(23,28)34)29(33)37-25-15-24(10-9-19(2)13-18)39-30(16-25)12-11-20(3)22(5)38-30/h6-9,14,18,20,22,24-26,28,34-35H,10-13,15-17H2,1-5H3/b7-6+,19-9+,23-8+,32-27+/t18-,20-,22+,24+,25-,26-,28+,30-,31+/m0/s1
InChi Key
VDBGCWFGLMXRIK-QXMUHYOBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Milbemycin A3 oxime is an anthelmintic, a derivative of milbemycin A3 (Item No. 18360), and a component of milbemycin oxide (Item No. 17164).1 It reduces the number of microfilariae of the heartworm D. immitis in the blood of naturally infested dogs by 85.2% when administered at a dose of 0.05 mg/kg. Formulations containing milbemycin A3 oxime, in combination with milbemycin A4 oxime, have been used in the treatment of parasitic infections in dogs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsukamoto, Y., Sato, K., Mio, S., et al. Synthesis of 5-keto-5-oxime derivatives of milbemycins and their activities against microfilariae. Agric. Biol. Chem. 55(10), 2615-2621 (1991).