A fungal metabolite
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Sultriecin

Item No. 27976

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5S,6S)-5,6-dihydro-5-hydroxy-6-[(1E,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-5-methyl-4-(phosphonooxy)-1,7,9,11-heptadecatetraen-1-yl]-2H-pyran-2-one, monosodium salt
CAS Number
131774-59-9
Synonyms
  • BU-3285T
  • Phostriecin
Molecular Formula
C23H34O8P • Na
Formula Weight
492.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C1O[C@@H](/C=C/C[C@H](OP([O-])(O)=O)[C@@H](C)[C@@H](O)/C=C\C=C/C=C/CCCCC)[C@@H](O)C=C1.[Na+]
InChi Code
InChI=1S/C23H35O8P.Na/c1-3-4-5-6-7-8-9-10-11-13-19(24)18(2)21(31-32(27,28)29)14-12-15-22-20(25)16-17-23(26)30-22;/h7-13,15-22,24-25H,3-6,14H2,1-2H3,(H2,27,28,29);/q;+1/p-1/b8-7+,10-9-,13-11-,15-12+;/t18-,19-,20-,21-,22-;/m0./s1
InChi Key
KLPJUUCINBGPOY-CRKRICINSA-M
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Sultriecin is a fungal metabolite originally isolated from S. roseiscleroticus.1 It is active against a panel of 15 fungal strains (MICs = 0.8-50 μg/ml). Sultriecin is cytotoxic to B16/F10, HCT116, Moser, P388, A549, and K562 cancer cells (IC50s = 37.7, 1.92, 0.85, 3.8, 4.14, and 0.67 μg/ml, respectively). It also inhibits RNA and protein synthesis in L1210 leukemia cells (IC50s = 5.5 and 2.4 μg/ml, respectively). Sultriecin (0.1-10 mg/kg) increases survival time in a B16/F10 syngeneic mouse melanoma model and a P388 murine leukemia model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohkuma, H., Naruse, N., Nishiyama, Y., et al. Sultriecin, a new antifungal and antitumor antibiotic from Streptomyces roseiscleroticus. Production, isolation, structure and biological activity. J. Antibiot. (Tokyo) 45(8), 1239-1249 (1992).