A synthetic estrogen
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Estrone 3-methyl ether

Item No. 27978

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methoxy-estra-1,3,5(10)-trien-17-one
CAS Number
1624-62-0
Synonyms
  • (+)-Estrone methyl ether
  • 3-O-methyl Estrone
  • NSC 88911
Molecular Formula
C19H24O2
Formula Weight
284.4
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/ml
SMILES
O=C1CC[C@@]2([H])[C@]3([H])CCC4=CC(OC)=CC=C4[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C19H24O2/c1-19-10-9-15-14-6-4-13(21-2)11-12(14)3-5-16(15)17(19)7-8-18(19)20/h4,6,11,15-17H,3,5,7-10H2,1-2H3/t15-,16-,17+,19+/m1/s1
InChi Key
BCWWDWHFBMPLFQ-VXNCWWDNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 mg

    $49

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    1 g

    $93

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    5 g

    $329

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    10 g

    $469

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    Product Description

    Estrone 3-methyl ether is a synthetic estrogen and derivative of estrone (Item No. 10006485).1 It stimulates proliferation of estrogen-dependent MCF-7 breast cancer cells in vitro when used at concentrations ranging from 0.16 to 20 μM but lacks estrogen receptor (ER) binding activity (IC50s = >100 μM for ERα and ERβ). Estrone 3-methyl ether has been used in the synthesis of various estrogen receptor modulators.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alsayari, A., Kopel, L., Ahmed, M.S., et al. Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents. Steroids 118, 32-40 (2017).

    2. Kuznetsov, Y.V., Levina, I.S., Scherbakov, A.M., et al. New estrogen receptor antagonists. 3,20-Dihydroxy-19-norpregna-1,3,5(10)-trienes: Synthesis, molecular modeling, and biological evaluation. Eur. J. Med. Chem. 143, 670-682 (2018).