A contact sensitizing agent
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Diphencyprone

Item No. 27982

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-diphenyl-2-cyclopropen-1-one
CAS Number
886-38-4
Synonyms
  • Diphenylcyclopropenone
  • DPC
  • NSC 57541
Molecular Formula
C15H10O
Formula Weight
206.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 14 mg/ml
λmax
220, 227, 299 nm
SMILES
O=C1C(C2=CC=CC=C2)=C1C3=CC=CC=C3
InChi Code
InChI=1S/C15H10O/c16-15-13(11-7-3-1-4-8-11)14(15)12-9-5-2-6-10-12/h1-10H
InChi Key
HCIBTBXNLVOFER-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $37

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    1 g

    $62

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    5 g

    $194

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    10 g

    $349

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    Product Description

    Diphencyprone (DCP) is a contact sensitizing agent.1,2,3 Pretreatment with DCP reduces symptom severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (1-10) (MBP1-10).1 It enhances IL-10 production and antigen-specific IgG2a antibody responses and reduces anaphylaxis and asthma induced by ovalbumin in mice when administered during ovalbumin immunization at a concentration of 1% v/v.2 Topical administration of DCP increases intrafollicular CD4+ and CD8+ T cells, reduces upper dermal inflammation, and stimulates hair growth in the C3H/HeJ mouse model of alopecia areta.3 Formulations containing DCP have been used in the treatment of alopecia areta.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meister, M., Tounsi, A., Gaffal, E., et al. Self-antigen presentation by keratinocytes in the inflamed adult skin modulates T-cell auto-reactivity. J. Invest. Dermatol. 135(8), 1996-2004 (2015).

    2. von Moos, S., Johansen, P., Waeckerle-Men, Y., et al. The contact sensitizer diphenylcyclopropenone has adjuvant properties in mice and potential application in epicutaneous immunotherapy. Allergy 67(5), 638-646 (2012).

    3. Shapiro, J., Sundberg, J.P., Bissonnette, R.P., et al. Alopecia areata-like hair loss in C3H/HeJ mice and DEBR rats can be reversed using topical diphencyprone. J. Investig. Dermatol. Symp. Proc. 4(3), 239 (1999).