A very long-chain fatty alcohol with diverse biological activities
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1-Octacosanol

Item No. 28010

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
557-61-9
Synonyms
  • FOH 28:0
  • Montanyl Alcohol
  • NSC 10770
  • NSC 57768
Molecular Formula
C28H58O
Formula Weight
410.8
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
SMILES
OCCCCCCCCCCCCCCCCCCCCCCCCCCCC
InChi Code
InChI=1S/C28H58O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29/h29H,2-28H2,1H3
InChi Key
CNNRPFQICPFDPO-UHFFFAOYSA-N
Side Chain Carbon Sum
28:0
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $60

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    500 mg

    $268

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    1 g

    $505

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    Product Description

    1-Octacosanol is a very long-chain fatty alcohol that has diverse biological activities, including antibacterial, antifungal, anti-inflammatory, and antioxidative properties.1,2,3 It is active against the bacteria K. pneumoniae, S. flexneri, S. typhi, and E. faecalis (MICs = 4, 8, 2, and 32 µg/ml, respectively), as well as the pathogenic fungi T. ajelloi and T. rubrum (MICs = 4 and 32 µg/ml, respectively), but not the yeast C. albicans, C. lusitaniae, or C. krusei.1 It reduces the expression of TNF-α, inducible nitric oxide synthase (iNOS), IL-1β, and IL-6 in RAW 264.7 cells stimulated with LPS when used at concentrations of 30 and 100 µg/ml.3 1-Octacosanol (100 mg/kg per day) increases body weight, decreases diarrhea and hematochezia, and improves histopathological and morphological changes in the colon in a mouse model of ulcerative colitis induced by dextran sulfate sodium (DSS; Item No. 23250). 1-Octacosanol (10, 50, or 100 mg/kg) reduces carbon tetrachloride-induced increases in serum transaminase, hepatic myeloperoxidase, and hepatic xanthine oxidase activity, as well as lipid peroxidation, in a rat model of acute liver injury progression.2 It also reverses decreases in hepatic superoxide dismutase and catalase activity, as well as glutathione (GSH) levels, in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tchakam, P.D., Lunga, P.K., Kowa, T.K., et al. Antimicrobial and antioxidant activities of the extracts and compounds from the leaves of Psorospermum aurantiacum Engl. and Hypericum lanceolatum Lam. BMC Complement. Altern. Med. 12:136, (2012).

    2. Ohta, Y., Ohashi, K., Matsura, T., et al. Octacosanol attenuates disrupted hepatic reactive oxygen species metabolism associated with acute liver injury progression in rats intoxicated with carbon tetrachloride. J. Clin. Biochem. Nutr. 42(2), 118-125 (2008).

    3. Guo, T., Lin, Q., Li, X., et al. Octacosanol attenuates inflammation in both RAW264.7 macrophages and a mouse model of colitis. J. Agric. Food Chem. 65(18), 3647-3658 (2017).