An antiulcerative and gastroprotective agent
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Ecabet (sodium salt)

Item No. 28013

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-1-phenanthrenecarboxylic acid, monosodium salt
CAS Number
86408-72-2
Synonyms
  • TA-2711
Molecular Formula
C20H27O5S • Na
Formula Weight
402.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 3 mg/ml
λmax
222 nm
SMILES
[O-]S(C1=CC2=C(C=C1C(C)C)CC[C@@]3([H])[C@](C)(C(O)=O)CCC[C@@]32C)(=O)=O.[Na+]
InChi Code
InChI=1S/C20H28O5S.Na/c1-12(2)14-10-13-6-7-17-19(3,8-5-9-20(17,4)18(21)22)15(13)11-16(14)26(23,24)25;/h10-12,17H,5-9H2,1-4H3,(H,21,22)(H,23,24,25);/q;+1/p-1/t17-,19-,20-;/m1./s1
InChi Key
RCVIHORGZULVTN-YGJXXQMASA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ecabet is an antiulcerative and gastroprotective agent.1,2,3,4 It reduces the viability of H. pylori grown under urea-supplemented acidic conditions in a concentration-dependent manner.1 Ecabet inhibits H. pylori urease activity in a pH-dependent manner (IC50s = 2.1-2.6 and >16 mg/ml at pH values of 5 and 8, respectively). It inhibits adhesion of H. pylori to MKN-28 cells when used at concentrations of 1 and 2 mg/ml.2 In vivo, ecabet (25 and 100 mg/kg, p.o.) increases levels of prostaglandin E2 (PGE2; Item No. 14010) in rat gastric mucosa.3 It inhibits formation of hemorrhagic lesions in esophageal mucosa and reduces gastric juice pepsin activity in a rat model of reflux induced by fore-stomach and pyloric ligation when administered at a dose of 30 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, Y., Shibata, K., Hongo, A., et al. Ecabet sodium, a locally acting antiulcer drug, inhibits urease activity of Helicobacter pylori. Eur. J. Pharmacol. 345(2), 193-198 (1998).

    2. Hayashi, S., Sugiyama, T., Yachi, A., et al. Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells. J. Gastroenterol. 32(5), 593-597 (1997).

    3. Kinoshita, M., Iwasaki, H., Yasoshima, A., et al. Effects of ecabet sodium (TA-2711), a new antiulcer agent, on gastrointestinal mucosal prostanoid production and morphology in rats. Biol. Pharm. Bull. 16(12), 1220-1225 (1993).

    4. Okuyama, K., Saito, N., Kume, E., et al. Ecabet sodium prevents esophageal lesions induced by the reflux of gastric juice in rats. Inflammopharmacology 15(2), 90-94 (2007).