An active metabolite of zolmitriptan
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Parent Compound(s)
15871Zolmitriptan
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N-desmethyl Zolmitriptan

Item No. 28058

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4(S)-[[3-[2-(methylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone
CAS Number
139264-35-0
Synonyms
  • 183C91
  • DZT
Molecular Formula
C15H19N3O2
Formula Weight
273.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
CNCCC1=CNC2=CC=C(C[C@H]3COC(N3)=O)C=C21
InChi Code
InChI=1S/C15H19N3O2/c1-16-5-4-11-8-17-14-3-2-10(7-13(11)14)6-12-9-20-15(19)18-12/h2-3,7-8,12,16-17H,4-6,9H2,1H3,(H,18,19)/t12-/m0/s1
InChi Key
QGGCHSMZXKNGCK-LBPRGKRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $929

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    Product Description

    N-desmethyl Zolmitriptan is an active metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist zolmitriptan (Item No. 15871).1 N-desmethyl Zolmitriptan is an agonist of 5-HT1B receptors that induces contraction of isolated human cerebral arteries (EC50 = 100 nM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patel, B., Suhagia, B.N., Jangid, A.G., et al. Systematic evaluation of matrix effect and cross-talk-free method for simultaneous determination of zolmitriptan and N-desmethyl zolmitriptan in human plasma: A sensitive LC-MS/MS method validation and its application to a clinical pharmacokinetic study. Biomed. Chromatogr. 30(3), 447-458 (2016).

    2. Nilsson, T., Longmore, J., Shaw, D., et al. Contractile 5-HT1B receptors in human cerebral arteries: Pharmacological characterization and localization with immunocytochemistry. Br. J. Pharmacol. 128(6), 1133-1140 (1999).