An ecdysone steroid hormone
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

2-O-Acetyl-20-hydroxyecdysone

Item No. 28063

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2β,3β,5β,22R)-2-(acetyloxy)-3,14,20,22,25-pentahydroxy-cholest-7-en-6-one
CAS Number
19536-25-5
Synonyms
  • β-Ecdysone 2-acetate
Molecular Formula
C29H46O8
Formula Weight
522.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
244 nm
SMILES
O=C1[C@]2([H])C[C@@H](O)[C@@H](OC(C)=O)C[C@]2(C)[C@]3([H])C([C@@](CC[C@]4([H])[C@]([C@H](O)CCC(C)(O)C)(O)C)(O)[C@]4(C)CC3)=C1
InChi Code
InChI=1S/C29H46O8/c1-16(30)37-22-15-26(4)17-7-11-27(5)23(28(6,35)24(33)9-10-25(2,3)34)8-12-29(27,36)18(17)13-20(31)19(26)14-21(22)32/h13,17,19,21-24,32-36H,7-12,14-15H2,1-6H3/t17-,19-,21+,22-,23-,24+,26+,27+,28+,29+/m0/s1
InChi Key
TXLUXHSVMYTTCI-FORVDKSSSA-N
Origin
Plant/Cyanotis arachnoides
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $63

    Add

    5 mg

    $274

    Add

    10 mg

    $481

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    2-O-Acetyl-20-hydroxyecdysone is an ecdysone steroid hormone that has been found in plants and animals.1 It completely inhibits the growth of the bacteria S. aureus, E. coli, and P. vulgaris, as well as the fungi C. albicans, A. alternata, and F. solani when used at a concentration of 10 µg/ml. 2-O-Acetyl-20-hydroxyecdysone (50 µM) increases aggregation of amyloid-β (1-42) (Aβ42), increases fibril formation by 60%, and decreases oligomer levels in cell-free assays.2 It reduces Aβ42-induced cytotoxicity of SH-SY5Y cells when used at concentrations of 5 and 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shirshova, T.I., Politova, N.K., Burtseva, S.A., et al. Antimicrobial activity of natural ecdysteroids from Serratula coronata L. and their acyl derivatives. Pharm. Chem. J. 40(5), 268–271 (2006).

    2. Yang, S.-G., Zhang, X., Sun, X.-S., et al. Diverse ecdysterones show different effects on amyloid-β42 aggregation but all uniformly inhibit amyloid-β42-induced cytotoxicity. J. Alzheimers. Dis. 22(1), 107-117 (2010).