A fungal metabolite
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Tenellin

Item No. 28090

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(2E,4E,6R)-4,6-dimethyl-1-oxo-2,4-octadien-1-yl]-1,4-dihydroxy-5-(4-hydroxyphenyl)-2(1H)-pyridinone
CAS Number
53823-15-7
Molecular Formula
C21H23NO5
Formula Weight
369.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
OC1=CC=C(C(C(O)=C2C(/C=C/C(C)=C/[C@H](C)CC)=O)=CN(O)C2=O)C=C1
InChi Code
InChI=1S/C21H23NO5/c1-4-13(2)11-14(3)5-10-18(24)19-20(25)17(12-22(27)21(19)26)15-6-8-16(23)9-7-15/h5-13,23,25,27H,4H2,1-3H3/b10-5+,14-11+/t13-/m1/s1
InChi Key
YELFBSBOFKWHSL-UCFWAISOSA-N
Origin
Fungus/Beauveria sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $340

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    5 mg

    $1,020

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    Product Description

    Tenellin is a fungal metabolite that has been found in Beauveria.1 It inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocytes by 51, 57, and 74%, respectively, when used at a concentration of 200 μg/ml.1 Tenellin is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of­ 4.84 and 11.95 μM, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jeffs, L.B., and Khachatourians, G.G. Toxic properties of Beauveria pigments on erythrocyte membranes. Toxicon. 35(8), 1351-1356 (1997).

    2. Arboleda Valencia, J.W., Gaitán Bustamante, A.L., Jiménez, A.V., et al. Cytotoxic activity of fungal metabolites from the pathogenic fungus Beauveria bassiana: An intraspecific evaluation of beauvericin production. Curr. Microbiol. 63(3), 306-312 (2011).