A fungal metabolite
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SCH 38519

Item No. 28092

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[3aR-(3aα,5α,9β,10β,11α,13β,14bα)]-11-(dimethylamino)-3,3a,5,10,11,12,13,14b-octahydro-7,10-dihydroxy-5,9-dimethyl-9,13-epoxycyclohepta[7,8]naphtho[2,3-d]furo[3,2-b]pyran-2,6,14(9H)-trione
CAS Number
114970-20-6
Molecular Formula
C24H25NO8
Formula Weight
455.5
Purity
≥85%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
λmax
218 nm
SMILES
OC1=CC2=C([C@@]3([H])C[C@@H](N(C)C)[C@H](O)[C@]2(C)O3)C4=C1C(C([C@@H](C)O[C@@](C5)([H])[C@]6([H])OC5=O)=C6C4=O)=O
InChi Code
InChI=1S/C24H25NO8/c1-8-15-19(22-13(31-8)7-14(27)32-22)21(29)18-16-9(5-11(26)17(18)20(15)28)24(2)23(30)10(25(3)4)6-12(16)33-24/h5,8,10,12-13,22-23,26,30H,6-7H2,1-4H3/t8-,10-,12-,13-,22+,23+,24-/m1/s1
InChi Key
JZGRDBGLULKCDD-HFJLKIIDSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    SCH 38519 is an isochromanequinone fungal metabolite originally isolated from Thermomonospora.1 It inhibits aggregation induced by thrombin (Item No. 13188), as well as inhibits serotonin secretion in human platelets (IC50s = 68 and 61 µg/ml, respectively).2 It inhibits the growth of various Gram-negative and Gram-positive bacteria (mean MICs = 122.1 and 0.92 µg/ml, respectively).

    WARNING This product is not for human or veterinary use.