An internal standard for the quantification of nevirapine
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Unlabeled Version(s)
15117Nevirapine
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Nevirapine-d4

Item No. 28093

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11-cyclopropyl-2,2,3,3-d4-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
CAS Number
1051418-95-1
Synonyms
  • NVP-d4
Molecular Formula
C15H10D4N4O
Formula Weight
270.3
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 2.5 mg/ml
SMILES
O=C1C2=C(N=CC=C2)N(C3C([2H])([2H])C3([2H])[2H])C4=C(C(C)=CC=N4)N1
InChi Code
InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)/i4D2,5D2
InChi Key
NQDJXKOVJZTUJA-CQOLUAMGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Cayman Chemical
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    Product Description

    Nevirapine-d4 is intended for use as an internal standard for the quantification of nevirapine (Item No. 15117) by GC- or LC-MS. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).1 It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50 = 0.45 μM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection.2 Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grobler, J.A., Dornadula, G., Rice, M.R., et al. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. The Journal of Biological Chemisty 282(11), 8005-8010 (2007).

    2. Grob, P.M., Cao, Y., Muchmore, E., et al. Prophylaxis against HIV-1 infection in chimpanzees by nevirapine, a nonnucleoside inhibitor of reverse transcriptase. Nat. Med. 3(6), 665-670 (1997).