An antibiotic
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Saccharocarcin A

Item No. 28094

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10-[[4-(acetylamino)-2,4,6-trideoxy-3-C-methylhexopyranosyl]oxy]-4-[[O-2,6-dideoxyhexopyranosyl-(1→4)-O-2,6-dideoxy-3-O-(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)hexopyranosyl-(1→4)-2,6-dideoxyhexopyranosyl]oxy]-15-ethyl-2,3,4,4a,6a,9,10,12a,15,16,20a,20b-dodecahydro-21-hydroxy-1,3,7,9,11,20a-hexamethyl-18H-16a,19-metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione
CAS Number
158475-32-2
Molecular Formula
C67H101NO20
Formula Weight
1240.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
CCC1C=CC(C2(OC3=O)C1)/C=C(C)\C(OC4OC(C)C(NC(C)=O)C(C)(O)C4)C(C)/C=C(C)\C(C=CC5C6C(C)CC(C)C5OC7OC(C)C(OC8CC(OC9CCC(O)C(C)O9)C(OC%10OC(C)C(O)C(O)C%10)C(C)O8)C(O)C7)C6(C)C(C3=C2O)=O
InChi Code
InChI=1S/C67H101NO20/c1-15-41-16-17-42-24-34(6)57(87-53-29-65(13,77)61(39(11)82-53)68-40(12)69)32(4)22-30(2)44-19-18-43-55(66(44,14)62(74)54-63(75)67(42,28-41)88-64(54)76)31(3)23-33(5)58(43)84-51-26-47(72)59(37(9)80-51)85-52-27-48(83-49-21-20-45(70)35(7)78-49)60(38(10)81-52)86-50-25-46(71)56(73)36(8)79-50/h16-19,22,24,31-33,35-39,41-53,55-61,70-73,75,77H,15,20-21,23,25-29H2,1-14H3,(H,68,69)/b30-22-,34-24-
InChi Key
JAMDOBKUFOFTAO-CBSOLZSTSA-N
Origin
Bacterium/Amycolatopsis sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica.1 It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg/ml.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Horan, A.C., Shearer, M.C., Hegde, V., et al. A family of novel macrocyclic lactones, the saccharocarcins produced by Saccharothrix aerocolonigenes subsp. antibiotica. I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot. (Tokyo) 50(2), 119-125 (1997).