A fungal metabolite with antibacterial activity
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Nybomycin

Item No. 28099

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-(hydroxymethyl)-6,11-dimethyl-2H,4H-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11H)-dione
CAS Number
30408-30-1
Synonyms
  • NSC 613948
Molecular Formula
C16H14N2O4
Formula Weight
298.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetic Acid (80%): Warmed
SMILES
CN(C(C=C1CO)=O)C2=C1C=C(C(C)=C3)C4=C2OCN4C3=O
InChi Code
InChI=1S/C16H14N2O4/c1-8-3-13(21)18-7-22-16-14-11(5-10(8)15(16)18)9(6-19)4-12(20)17(14)2/h3-5,19H,6-7H2,1-2H3
InChi Key
HKMUGCUFXWTNSP-UHFFFAOYSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $304

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    2.5 mg

    $983

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    Product Description

    Nybomycin is a fungal metabolite originally isolated from Streptomyces sp. A717 and has antibacterial activity.1 It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae (MICs = 0.025, 2, 0.8, 0.2, and 0.003 μg/ml, respectively). Nybomycin is also active against M. tuberculosis and M. bovis (MICs = 4.5 and 1 μg/ml, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Strelitz, F., Flon, H., and Asheshov, I.N. Nybomycin, a new antibiotic with antiphage and antibacterial properties. Proc. Natl. Acad. Sci. USA 41(9), 620-624 (1955).

    2. Arai, M., Kamiya, K., Pruksakorn, P., et al. Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. Bioorg. Med. Chem. 23(13), 3534-3541 (2015).