A glycoalkaloid with anticancer activity
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Product Categories

Product Type

Biochemicals
Natural Products
Alkaloids

Research Area

Cancer
Cell Death

Solamargine

Item No. 28110

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,22α,25R)-spirosol-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside
CAS Number
20311-51-7
Synonyms
  • NSC 407810
  • α-Solamargine
Molecular Formula
C45H73NO15
Formula Weight
868.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
OC[C@H]([C@@H](O[C@@]1([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1)[C@H](O)[C@H]2O[C@@]3([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)O[C@@]2([H])O[C@H](C4)CC[C@@]5(C)C4=CC[C@]6([H])[C@]5([H])CC[C@@]7(C)[C@@]6([H])C[C@@]8([H])[C@]7([H])[C@H](C)[C@]9(NC[C@H](C)CC9)O8
InChi Code
InChI=1S/C45H73NO15/c1-19-9-14-45(46-17-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(53)34(51)32(49)22(4)56-41)37(54)38(29(18-47)58-42)59-40-35(52)33(50)31(48)21(3)55-40/h7,19-22,24-42,46-54H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1
InChi Key
MBWUSSKCCUMJHO-ZGXDEBHDSA-N
Origin
Plant/Solanum nigrum
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $315

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    10 mg

    $407

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    Cayman Chemical
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    Product Description

    Solamargine is a glycoalkaloid that has been found in S. lycocarpum and has anticancer activity.1 It decreases viability of H1650, H1975, PC-9, A549, and H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 6 µM. Solamargine increases ERK1/2 phosphorylation and decreases the expression of DNA methyltranferase 1 (DNMT1) in H1299 and A549 cells. It reduces tumor growth in an A549 mouse xenograft model when administered at a dose of 8 mg/kg per day. Solamargine increases ERK1/2 phosphorylation and reduces the expression of the prostaglandin E2 receptor, DNMT1, and c-Jun in tumor tissue.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, Y., Tang, Q., Xiao, Q., et al. Targeting EP4 downstream c-Jun through ERK1/2-mediated reduction of DNMT1 reveals novel mechanism of solamargine-inhibited growth of lung cancer cells. J. Cell. Mol. Med. 21(2), 222-233 (2017).