An alkaloid with diverse biological activities
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Solasodine

Item No. 28112

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,22α,25R)-spirosol-5-en-3-ol
CAS Number
126-17-0
Synonyms
  • NSC 179187
  • NSC 178260
  • Purapuridine
  • Solancarpidine
  • Solasod-5-en-3β-ol
  • (−)-Solasodine
Molecular Formula
C27H43NO2
Formula Weight
413.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlEthanol: 1 mg/ml
SMILES
O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])C[C@@]5([H])[C@]4([H])[C@H](C)[C@]6(NC[C@H](C)CC6)O5
InChi Code
InChI=1S/C27H43NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28-29H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
InChi Key
KWVISVAMQJWJSZ-VKROHFNGSA-N
Origin
Plant/Solanum aviculare
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $81

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    10 mg

    $128

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    25 mg

    $258

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    50 mg

    $475

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    Cayman Chemical
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    Product Description

    Solasodine is an alkaloid that has been found in Solanum and has diverse biological activities.1,2,3 It reduces glutamate-induced excitotoxicity in PC12 cells when used at a concentration of 40 µM.1 Solasodine (40 µM) inhibits cell invasion and migration of, as well as reverses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in, HCT116 cells.2 Solasodine (30 and 50 mg/kg) reduces tumor growth and inhibits EMT in an HCT116 mouse xenograft model. It also reduces paw edema induced by carrageenan or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in rats when administered at a dose of 75 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. García-Pupo, L., Zaldo-Castro, A., Exarchou, V., et al. In vitro neuroprotective and anti-inflammatory activities of natural and semi-synthetic spirosteroid analogues. Molecules 21(8), 992 (2016).

    2. Zhuang, Y., Wu, C., Zhou, J., et al. Solasodine reverses stemness and epithelial-mesenchymal transition in human colorectal cancer. Biochem. Biophys. Res. Commun. 505(2), 485-491 (2018).

    3. Pandurangan, A., Khosa, R.L., and Hemalatha, S. Anti-inflammatory activity of an alkaloid from Solanum trilobatum on acute and chronic inflammation models. Nat. Prod. Res. 25(12), 1132-1141 (2011).