A colorimetric caspase-1 and -4 substrate
Related Products
Alternative(s)
17487Ac-YVAD-pNA (trifluoroacetate salt)
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Suc-YVAD-pNA

Item No. 28135

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-carboxy-1-oxopropyl)-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine
CAS Number
208264-84-0
Synonyms
  • Caspase-1 and Caspase-4 Chromogenic Substrate
  • Suc-Tyr-Val-Ala-Asp-p-nitroanilide
Molecular Formula
C31H38N6O12
Formula Weight
686.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetic Acid (50%): Soluble
λmax
223, 317 nm
SMILES
O=C([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(CCC(O)=O)=O)CC1=CC=C(O)C=C1)=O)=O)=O)NC2=CC=C([N+]([O-])=O)C=C2
InChi Code
InChI=1S/C31H38N6O12/c1-16(2)27(36-30(46)22(34-24(39)12-13-25(40)41)14-18-4-10-21(38)11-5-18)31(47)32-17(3)28(44)35-23(15-26(42)43)29(45)33-19-6-8-20(9-7-19)37(48)49/h4-11,16-17,22-23,27,38H,12-15H2,1-3H3,(H,32,47)(H,33,45)(H,34,39)(H,35,44)(H,36,46)(H,40,41)(H,42,43)/t17-,22-,23-,27-/m0/s1
InChi Key
APPSYVHVOCTIDH-ZBBFOALVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

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    Product Description

    Suc-YVAD-pNA is a colorimetric substrate for caspase-1/interleukin-1β-converting enzyme (ICE) and caspase-4.1 Caspase-1 and caspase-4 preferentially bind to and cleave the Tyr-Val-Ala-Asp (YVAD) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of caspase-1 and caspase-4 activity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Margolin, N., Raybuck, S.A., Wilson, K.P., et al. Substrate and inhibitor specificity of interleukin-1β-converting enzyme and related caspases. The Journal of Biological Chemisty 272(11), 7223-7228 (1997).