A peptide fragment of histone H3
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Histone H3 (23-34) (human, mouse, rat, bovine) (trifluoroacetate salt)

Item No. 28139

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycyl-glycine, trifluoroacetate salt
Synonyms
  • KAARKSAPATGG
Molecular Formula
C46H83N17O15 • XCF3COOH
Formula Weight
1114.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(NCC(NCC(O)=O)=O)=O)=O)C)=O)=O)C)=O)=O)=O)=O)C)=O)C)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C46H83N17O15.C2HF3O2/c1-23(56-39(72)28(49)12-6-8-16-47)36(69)55-24(2)37(70)59-30(14-10-18-52-46(50)51)40(73)60-29(13-7-9-17-48)41(74)61-31(22-64)42(75)58-26(4)45(78)63-19-11-15-32(63)43(76)57-25(3)38(71)62-35(27(5)65)44(77)54-20-33(66)53-21-34(67)68;3-2(4,5)1(6)7/h23-32,35,64-65H,6-22,47-49H2,1-5H3,(H,53,66)(H,54,77)(H,55,69)(H,56,72)(H,57,76)(H,58,75)(H,59,70)(H,60,73)(H,61,74)(H,62,71)(H,67,68)(H4,50,51,52);(H,6,7)/t23-,24-,25-,26-,27+,28-,29-,30-,31-,32-,35-;/m0./s1
InChi Key
RMWCDRURZRBGQS-PMOBBTDUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $267

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    Product Description

    Histone H3 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. It contains lysine residues at positions 23 and 27 that are subject to methylation and acetylation and have a role in the regulation of gene expression and a serine residue at position 28 that is subject to phosphorylation during mitosis.1,2,3 Histone H3 (23-34) has been used in epitope mapping of the lupus-derived monoclonal antibody BT164.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat. Struct. Mol. Biol. 14(11), 1008-1016 (2007).

    2. Garcia, B.A., Hake, S.B., Diaz, R.L., et al. Organismal differences in post-translational modifications in histones H3 and H4. The Journal of Biological Chemisty 282(10), 7641-7655 (2007).

    3. Hake, S.B., Garcia, B.A., Kauer, M., et al. Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Proc. Natl. Acad. Sci. USA 102(18), 6344-6349 (2005).

    4. van Bavel, C.C., Dieker, J., Kroeze, Y., et al. Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus. Ann. Rheum. Dis. 70(1), 201-207 (2011).