A peptide fragment of histone H3
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Histone H3K27Me1 (23-34) (trifluoroacetate salt)

Item No. 28141

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-alanyl-L-alanyl-L-arginyl-N6-methyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycine, trifluoroacetate salt
Synonyms
  • Histone H3 (23-34) (Lys27me1)
  • KAAR-K(Me1)-SAPATGG
  • [Lys(Me1)27]-Histone H3 (23-34)
Molecular Formula
C47H85N17O15 • XCF3COOH
Formula Weight
1128.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
CNCCCC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(NCC(NCC(O)=O)=O)=O)=O)C)=O)=O)C)=O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)N[H])=O)C)=O)C)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C47H85N17O15.C2HF3O2/c1-24(57-40(73)29(49)13-7-9-17-48)37(70)56-25(2)38(71)60-31(15-11-19-53-47(50)51)41(74)61-30(14-8-10-18-52-6)42(75)62-32(23-65)43(76)59-27(4)46(79)64-20-12-16-33(64)44(77)58-26(3)39(72)63-36(28(5)66)45(78)55-21-34(67)54-22-35(68)69;3-2(4,5)1(6)7/h24-33,36,52,65-66H,7-23,48-49H2,1-6H3,(H,54,67)(H,55,78)(H,56,70)(H,57,73)(H,58,77)(H,59,76)(H,60,71)(H,61,74)(H,62,75)(H,63,72)(H,68,69)(H4,50,51,53);(H,6,7)/t24-,25-,26-,27-,28+,29-,30-,31-,32-,33-,36-;/m0./s1
InChi Key
QQIBHWIZVMWSMM-GGLXIBEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $334

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    Product Description

    Histone H3K27Me1 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. Monomethylation of histone H3 at lysine 27 is associated with actively transcribed genes and positively correlates with H3K36 trimethylation.1 Levels of H3K27Me1 are increased in tumor tissue isolated from patients with metastatic hormone-naïve and castration-resistant prostate cancer.2 Histone H3K27Me1 (23-34) has been used in epitope mapping of the lupus-derived monoclonal antibody BT164.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ferrari, K.J., Scelfo, A., Jammula, S., et al. Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity. Mol. Cell 53(1), 49-62 (2014).

    2. Ellinger, J., Kahl, P., von der Gathen, J., et al. Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer. Cancer Invest. 30(2), 92-97 (2012).

    3. van Bavel, C.C., Dieker, J., Kroeze, Y., et al. Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus. Ann. Rheum. Dis. 70(1), 201-207 (2011).