A peptide fragment of histone H3
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Histone H3K27Me2 (23-34) (trifluoroacetate salt)

Item No. 28142

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-alanyl-L-alanyl-L-arginyl-N6,N6-dimethyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycine, trifluoroacetate salt
Synonyms
  • [Lys(Me2)27]-Histone H3 (23-34)
  • Histone H3 (23-34) (Lys27me2)
  • KAAR-K(Me2)-SAPATGG
Molecular Formula
C48H87N17O15 • XCF3COOH
Formula Weight
1142.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
CN(C)CCCC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(NCC(NCC(O)=O)=O)=O)=O)C)=O)=O)C)=O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)N[H])=O)C)=O)C)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C48H87N17O15.C2HF3O2/c1-25(57-41(74)30(50)14-8-10-18-49)38(71)56-26(2)39(72)60-32(16-12-19-53-48(51)52)42(75)61-31(15-9-11-20-64(6)7)43(76)62-33(24-66)44(77)59-28(4)47(80)65-21-13-17-34(65)45(78)58-27(3)40(73)63-37(29(5)67)46(79)55-22-35(68)54-23-36(69)70;3-2(4,5)1(6)7/h25-34,37,66-67H,8-24,49-50H2,1-7H3,(H,54,68)(H,55,79)(H,56,71)(H,57,74)(H,58,78)(H,59,77)(H,60,72)(H,61,75)(H,62,76)(H,63,73)(H,69,70)(H4,51,52,53);(H,6,7)/t25-,26-,27-,28-,29+,30-,31-,32-,33-,34-,37-;/m0./s1
InChi Key
DTIUMEJOLNFAMY-IVCKIZDSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $307

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    Product Description

    Histone H3K27Me2 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. Dimethylation of H3K27 is present on large chromatin domains across approximately 70% of total histone H3 and prevents firing of non-cell type-specific enhancers.1 H3K27Me2 accumulates in gene bodies of genes with low levels of expression in mouse embryonic stem cells. Histone H3K27Me2 (23-34) has been used in epitope mapping of the lupus-derived monoclonal antibody BT164.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ferrari, K.J., Scelfo, A., Jammula, S., et al. Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity. Mol. Cell 53(1), 49-62 (2014).

    2. van Bavel, C.C., Dieker, J., Kroeze, Y., et al. Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus. Ann. Rheum. Dis. 70(1), 201-207 (2011).