An antioxidant response element activator with cardioprotective activity
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BTZO-1

Item No. 28161

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-pyridinyl)-4H-1,3-benzothiazin-4-one
CAS Number
99420-15-2
Molecular Formula
C13H8N2OS
Formula Weight
240.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C1N=C(C2=NC=CC=C2)SC3=CC=CC=C31
InChi Code
InChI=1S/C13H8N2OS/c16-12-9-5-1-2-7-11(9)17-13(15-12)10-6-3-4-8-14-10/h1-8H
InChi Key
GBAKVEWPYUIGHN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $81

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    10 mg

    $152

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    25 mg

    $357

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    Product Description

    BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.1 It increases expression of an ARE-luciferase reporter construct in H9c2 cells in a concentration-dependent manner as well as mRNA expression of the ARE-regulated genes for the glutathione S-transferase Ya subunit (GST Ya) and heme oxygenase-1 (HO-1) in neonatal rat cardiomyocytes. BTZO-1 binds to macrophage migration inhibitory factor (MIF; Kd = 68.6 nM) and increases expression of GST Ya in H9c2 cells in a MIF-dependent manner when used at a concentration of 3 μM. It inhibits cell death induced by serum deprivation or doxorubicin (Item No. 15007) in neonatal rat cardiomyocytes in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kimura, H., Sato, Y., Tajima, Y., et al. BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression. Chem. Biol. 17(12), 1282-1294 (2010).