A fungal metabolite with diverse biological activities
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Leucinostatin A

Item No. 28190

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
76600-38-9
Synonyms
  • P168
Molecular Formula
C62H111N11O13
Formula Weight
1218.6
Purity
≥85%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
CC(C)C[C@H](NC([C@H](CC(C)C)NC(C(C)(C)NC([C@H]([C@@H](C(C)C)O)NC([C@@H](NC([C@H]1N(C(/C=C/[C@@H](C)CC)=O)C[C@@H](C)C1)=O)C[C@H](C)C[C@H](O)CC(CC)=O)=O)=O)=O)=O)C(NC(C)(C)C(NC(C)(C)C(NCCC(N[C@@H](C)CN(C)C)=O)=O)=O)=O
InChi Code
InChI=1S/C62H111N11O13/c1-21-38(9)23-24-49(77)73-33-40(11)31-47(73)55(82)66-46(30-39(10)29-43(75)32-42(74)22-2)53(80)68-50(51(78)37(7)8)56(83)70-61(15,16)58(85)67-44(27-35(3)4)52(79)65-45(28-36(5)6)54(81)69-62(17,18)59(86)71-60(13,14)57(84)63-26-25-48(76)64-41(12)34-72(19)20/h23-24,35-41,43-47,50-51,75,78H,21-22,25-34H2,1-20H3,(H,63,84)(H,64,76)(H,65,79)(H,66,82)(H,67,85)(H,68,80)(H,69,81)(H,70,83)(H,71,86)/b24-23+/t38-,39+,40-,41-,43-,44-,45-,46-,47-,50-,51+/m0/s1
InChi Key
FOAIGCPESMNWQP-TXVCAPCZSA-N
Origin
Fungus/Paecilomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

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    Product Description

    Leucinostatin A is a fungal metabolite originally isolated from P. lilacinus with diverse biological activities.1 It is active against P. oryzae, B. cinera, P. chrysogenum, X. oryzae, S. cerevisiae, and C. albicans fungi and B. subtilis, S. aureus, S. lutea, and M. phlei bacteria in a disc assay.1 Leucinostatin A (0.1-1 μg/ml) reduces T cell activation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) or an anti-CD3 antibody in a concentration-dependent manner.2 It inhibits proliferation of DU145 prostate cancer cells co-cultured with PrSC stromal cells in vitro (IC50 = 0.045 μg/ml).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Isogal, A., Suzuki, A., Higashikawa, S., et al. Isolation and biological activity of a peptidal antibiotic P168. Agric. Biol. Chem. 45(4), 1023-1024 (1981).

    2. Csermely, P., Radics, L., Rossi, C., et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim. Biophys. Acta 1221(2), 125-132 (1994).

    3. Abe, H., Kawada, M., Sakashita, C., et al. Structure-activity relationship study of leucinostatin A, a modulator of tumor-stroma interaction. Tetrahedron 74(38), 5129-5137 (2018).