A component of B. anthracis edema toxin
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Anthrax Edema Factor (EF) (recombinant from Bacillus anthracis)

Item No. 28210

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Purity
≥95% (estimated by SDS-PAGE)
Formulation (Request formulation change)
Each vial, when reconstituted with 100 µl in water, contains 0.1 mg of edema factor from Bacillus anthracis in 5 mM HEPES, 50 mM NaCl, pH 7.5
Solubility(Learn about Variance in Solubility)
Water: soluble
Shipping & Storage Information
Storage
4°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $277

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    Product Description

    Anthrax edema factor (EF) is a component of edema toxin (EdTx) produced by B. anthracis.1,2 It is comprised of an N-terminal protective antigen (PA) binding domain (PABD), an adenylyl cyclase domain, and a helical domain.2 Inactive EF binds oligomerized B. anthracis PA on the host cell surface. EF and PA, together known as EdTx, are endocytosed by the host cell, after which PA facilitates translocation of EF into the host cell cytoplasm. There, calmodulin binds the EF helical domain and activates its adenylyl cyclase activity, leading to an increase in intracellular cAMP.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, S., Moayeri, M., and Leppla, S.H. Anthrax lethal and edema toxins in anthrax pathogenesis. Trends Microbiol. 22(6), 317-325 (2014).

    2. Tang, W.-J., and Guo, Q. The adenylyl cyclase activity of anthrax edema factor. Mol. Aspects Med. 30(6), 423-430 (2009).