A virulence factor in B. pertussis
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Adenylate Cyclase Toxin from Bordetella pertussis (recombinant, frozen liquid)

Item No. 28211

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Adenylyl Cyclase Toxin
Purity
≥90% (estimated by SDS-PAGE)
Formulation (Request formulation change)
Each vial contains 50 µg of recombinant adenylate cyclase toxin in 39 µl of 0.05 M Tris-HCl, 8 M urea, pH 8.0
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µg

    $534

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    Product Description

    Adenylate cyclase toxin is a virulence factor in B. pertussis.1 It is composed of an adenylate cyclase domain that binds calmodulin and an RTX hemolysin domain that contains a pore-forming domain, an activation domain with two lysine acylation sites, calcium binding repeats, and a C-terminal secretion signal. The calcium binding repeat domain binds to complement receptor 3 (CD11b/CD18) on sentinel cells and the pore-forming domain allows entry of the adenylyl cyclase domain, which increases cAMP and calcium levels, permeabilizes the membrane, inhibits phagocytic functions, and may induce cell death through apoptosis or necrosis. Adenylate cyclase toxin has been used in the development of a microsphere-based multiplex antibody capture assay to quantify antibody amounts in acellular pertussis vaccines.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Novak, J., Cerny, O., Osickova, A., et al. Structure-function relationships underlying the capacity of Bordetella adenylate cyclase toxin to disarm host phagocytes. Toxins (Basel) 9(10), E300 (2017).

    2. Rajam, G., Carlone, G., Kim, E., et al. Development and validation of a robust multiplex serological assay to quantify antibodies specific to pertussis antigens. Biologicals 57, 9-20 (2019).