An internal standard for the quantification of cis-6-hexadecenoic acid
Related Products
Unlabeled Version(s)
9001845cis-6-Hexadecenoic Acid
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

cis-6-Hexadecenoic Acid-d19

Item No. 28227

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6Z-hexadecenoic-8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d19 acid
CAS Number
2692623-89-3
Synonyms
  • C16:1(6Z)-d19
  • C16:1Δ6-d19
  • C16:1ω10c-d19
  • FA 16:1-d19
  • Sapienic Acid-d19
Molecular Formula
C16H11D19O2
Formula Weight
273.5
Purity
≥99% deuterated forms (d1-d19)
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
SMILES
[2H]C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])([2H])/C=C\CCCCC(O)=O
InChi Code
InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h10-11H,2-9,12-15H2,1H3,(H,17,18)/b11-10-/i1D3,2D2,3D2,4D2,5D2,6D2,7D2,8D2,9D2
InChi Key
NNNVXFKZMRGJPM-XZHWPFOISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $121

    Add

    5 mg

    $576

    Add

    10 mg

    $968

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    cis-6-Hexadecenoic acid-d19 is intended for use as an internal standard for the quantification of cis-6-hexadecenoic acid (Item No. 9001845) by GC- or LC-MS. cis-6-Hexadecenoic acid is a monounsaturated fatty acid and is one of the primary fatty acids in human skin.1 cis-6-Hexadecenoic acid levels are increased in isolated sebum from the face and back of patients with acne.2 In contrast, levels are decreased in the non-lesional skin and isolated sebum of atopic dermatitis patients, which correlates with an increase in S. aureus in the sebum.1 It is active against S. aureus in vitro when used at a concentration of 5 µg/ml at pH 5.5.3 cis-6-Hexadecenoic acid disrupts membrane integrity, the proton motive force, increases membrane fluidity, and inhibits the electron transport chain in S. aureus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takigawa, H., Nakagawa, H., Kuzukawa, M., et al. Deficient production of hexadecenoic acid in the skin is associated in part with the vulnerability of atopic dermatitis patients to colonization by Staphylococcus aureus. Dermatology 211(3), 240-248 (2005).

    2. Li, W.-H., Zhang, Q., Flach, C.R., et al. In vitro modeling of unsaturated free fatty acid-mediated tissue impairments seen in acne lesions. Arch. Dermatol. Res. 309(7), 529-540 (2017).

    3. Cartron, M.L., England, S.R., Chiriac, A.I., et al. Bactericidal activity of the human skin fatty acid cis-6-hexadecanoic acid on Staphylococcus aureus. Antimicrob. Agents Chemother. 58(7), 3599-3609 (2014).