An L-type calcium channel blocker
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Lacidipine

Item No. 28270

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester
CAS Number
103890-78-4
Synonyms
  • GX 1048
  • GR 43659X
Molecular Formula
C26H33NO6
Formula Weight
455.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25mg/mLDMF:PBS (pH 7.2) (1:3): 0.25mg/mLDMSO: 20mg/mLEthanol: 5mg/ml
λmax
240, 284, 368 nm
SMILES
CC1=C(C(OCC)=O)C(C2=C(/C=C/C(OC(C)(C)C)=O)C=CC=C2)C(C(OCC)=O)=C(C)N1
InChi Code
InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+
InChi Key
GKQPCPXONLDCMU-CCEZHUSRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $107

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    250 mg

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    500 mg

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    1 g

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    Product Description

    Lacidipine is a dihydropyridine L-type calcium channel blocker.1 It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM.2 It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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