A broad-spectrum fluoroquinolone antibiotic
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Lomefloxacin (hydrochloride)

Item No. 28271

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride
CAS Number
98079-52-8
Synonyms
  • SC-47111
Molecular Formula
C17H19F2N3O3 • HCl
Formula Weight
387.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
287 nm
SMILES
CC1NCCN(C2=C(F)C=C(C(C(C(O)=O)=CN3CC)=O)C3=C2F)C1.Cl
InChi Code
InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
InChi Key
KXEBLAPZMOQCKO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic.1 In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC90s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 μg/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA; MIC90 = 3.13 μg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC90 = 0.1 μg/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED50s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth.2 Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hirose, T., Okezaki, E., Kato, H., et al. In vitro and in vivo activity of NY-198, a new difluorinated quinolone. Antimicrob. Agents Chemother. 31(6), 854-859 (1987).

    2. Piddock, L.J., Hall, M.C., and Wise, R. Mechanism of action of lomefloxacin. Antimicrob. Agents Chemother. 34(6), 1088-1093 (1990).