A class III antiarrhythmic agent
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Product Categories

Product Type

Biochemicals

Research Area

Cardiovascular System
Heart
Arrhythmia

Sematilide (hydrochloride)

Item No. 28272

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(diethylamino)ethyl]-4-[(methylsulfonyl)amino]-benzamide, monohydrochloride
CAS Number
101526-62-9
Synonyms
  • CK-1752A
Molecular Formula
C14H23N3O3S • HCl
Formula Weight
349.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMSO: 12 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
261 nm
SMILES
CS(NC1=CC=C(C(NCCN(CC)CC)=O)C=C1)(=O)=O.Cl
InChi Code
InChI=1S/C14H23N3O3S.ClH/c1-4-17(5-2)11-10-15-14(18)12-6-8-13(9-7-12)16-21(3,19)20;/h6-9,16H,4-5,10-11H2,1-3H3,(H,15,18);1H
InChi Key
OKXAJGDKHKNFAX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $134

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    25 mg

    $315

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    50 mg

    $516

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    Product Description

    Sematilide is a class III antiarrhythmic agent and an analog of sotalol (Item No. 16136).1 It prolongs electrically stimulated action potential duration (APD) and increases the effective refractory period (ERP) in isolated guinea pig left atria. Sematilide decreases spontaneous sinoatrial beating rates and induces ERP prolongation of the atrioventricular node in isolated perfused canine hearts.2 In situ, sematilide (1 mg/kg) increases ERP, prolonging cardiac refractoriness, in open-chest dog hearts. Sematilide (0.3-6 mg/kg) inhibits arrhythmias induced by programmed electrical stimulation (PES), but not coronary ligation and reperfusion, two-stage coronary ligation, adrenaline, or digitalis, in dogs.3 Formulations containing sematilide have been used in the treatment of arrhythmias.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ishii, Y., Muraki, K., Kurihara, A., et al. Effects of sematilide, a novel class III antiarrhythmic agent, on action potential in guinea pig atrium. Jpn. J. Pharmacol. 68(2), 175-182 (1995).

    2. Yamada, A., Motomura, S., and Hashimoto, K. Comparison of direct negative chronotropic and positive inotropic effects of sematilide to those of E-4031 and MS-551 and the reverse frequency-dependent prolongation of cardiac refractoriness of sematilide. J. Cardiovasc. Pharmacol. 27(1), 159-166 (1996).

    3. Xue, Y.X., Eto, K., Akie, Y., et al. Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models. Jpn. J. Pharmacol. 70(2), 129-138 (1996).