An inhibitor of COX-2
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Firocoxib

Item No. 28286

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
CAS Number
189954-96-9
Synonyms
  • ML-1785713
Molecular Formula
C17H20O5S
Formula Weight
336.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
210, 220, 291 nm
SMILES
O=C1C(OCC2CC2)=C(C3=CC=C(S(C)(=O)=O)C=C3)C(C)(C)O1
InChi Code
InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
InChi Key
FULAPETWGIGNMT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $49

    Add

    50 mg

    $213

    Add

    100 mg

    $400

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Firocoxib is a selective inhibitor of COX-2 (IC50s = 0.13 and 7.5 µM for COX-2 and COX-1, respectively, in isolated cat blood).1 It inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated dog, horse, and cat whole blood ex vivo.2,3,1 Firocoxib decreases lameness, induces analgesia, and improves range of motion in dogs and horses with osteoarthritis when administered at doses of 5 and 0.1 mg/kg per day, respectively.4,5 Formulations containing firocoxib have been used in dogs and horses with osteoarthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCann, M.E., Rickes, E.L., Hora, D.F., et al. In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in cats with lipopolysaccharide-induced pyrexia. Am. J. Vet. Res. 66(7), 1278-1284 (2005).

    2. Goodman, L., Torres, B., Punke, J., et al. Effects of firocoxib and tepoxalin on healing in a canine gastric mucosal injury model. J. Vet. Intern. Med. 23(1), 56-62 (2009).

    3. Barton, M.H., Paske, E., Norton, N., et al. Efficacy of cyclo-oxygenase inhibition by two commercially available firocoxib products in horses. Equine Vet. J. 46(1), 72-75 (2014).

    4. Pollmeier, M., Toulemonde, C., Fleishman, C., et al. Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis. Vet. Rec. 159(17), 547-551 (2006).

    5. Doucet, M.Y., Bertone, A.L., Hendrickson, D., et al. Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis. J. Am. Vet. Med. Assoc. 232(1), 91-97 (2008).