An activator of p53
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Kevetrin (hydrochloride)

Item No. 28288

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride
CAS Number
66592-89-0
Synonyms
  • 4-Isothioureidobutyronitrile
  • NSC 525990
Molecular Formula
C5H9N3S • HCl
Formula Weight
179.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
NC(SCCCC#N)=N.Cl
InChi Code
InChI=1S/C5H9N3S.ClH/c6-3-1-2-4-9-5(7)8;/h1-2,4H2,(H3,7,8);1H
InChi Key
NCXJZJFDQMKRKM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $115

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    25 mg

    $248

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    50 mg

    $427

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    Cayman Chemical
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    Product Description

    Kevetrin is an activator of p53.1,2 It increases levels of activated p53 and expression of p21 in A549 cells and decreases expression of the transcription factor E2F1 in a variety of cell lines.1,2 Kevetrin decreases cell viability in a panel of cancer cell lines with a mean IC50 value of 0.49 μM.3 It reduces tumor growth in MDA-MB-231, HT-29, PC3, HCT15, A549, NCI-H1975, CRL-1619, LNCaP, MIA PaCa, and SCC-5 mouse xenograft models when administered at a dose of 200 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kumar, A., Hiran, T., Holden, S.A., et al. Abstract 4470: Kevetrin™, a novel small molecule, activates p53, enhances expression of p21, induces cell cycle arrest and apoptosis in a human cancer cell line. Cancer Res. 71(8 Supp), 4470 (2011).

    2. Kumar, A., Holden, S.A., Chafai-Fadela, K., et al. Abstract 2874: Kevetrin targets both MDM2-p53 and Rb-E2F pathways in tumor suppression. Cancer Res. 72(8 Supp), 2874 (2012).

    3. Menon, K. Nitrile derivatives and their pharmaceutical use and compositions. (2012).