A TRPC6 channel blocker
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SAR7334 (hydrochloride)

Item No. 28292

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(1R,2R)-2-[(3R)-3-amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-benzonitrile, dihydrochloride
CAS Number
1333207-63-8
Molecular Formula
C21H22ClN3O • 2HCl
Formula Weight
440.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mLDMSO: 15 mg/mLEthanol: 25 mg/mLEthanol:PBS (pH 7.2) (1:5): 0.16mg/mL
λmax
211, 254 nm
SMILES
N[C@H](CCC1)CN1[C@H]2[C@H](OC3=C(Cl)C=C(C#N)C=C3)C4=CC=CC=C4C2.Cl.Cl
InChi Code
InChI=1S/C21H22ClN3O.2ClH/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25;;/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2;2*1H/t16-,19-,21-;;/m1../s1
InChi Key
LFMYIKNZNTZSJX-IQJQELQDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $41

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    1 mg

    $75

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    5 mg

    $312

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    Product Description

    SAR7334 is a transient receptor potential canonical 6 (TRPC6) channel blocker (IC50 = 7.9 nM).1 It is selective for TRPC6 over TRPC4 and TRPC5 (IC50s = 282 and 226 nM, respectively). SAR7334 (0.2-1 μM) blocks TRPC6-dependent hypoxia-induced vasoconstriction in isolated perfused and ventilated mouse lung. It also inhibits oxidative stress-induced apoptosis and increases autophagic flux in primary mouse renal proximal tubule cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maier, T., Follmann, M., Hessler, G., et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br. J. Pharmacol. 172(14), 3650-3660 (2015).

    2. Hou, X., Xiao, H., Zhang, Y., et al. Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. Cell Death Dis. 9(10), 1015 (2018).