A derivative of withaferin A with anticancer activity
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Death

4-oxo Withaferin A

Item No. 28295

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β,6β,22R)-5,6-epoxy-22,27-dihydroxy-1,4-dioxo-ergosta-2,24-dien-26-oic acid, δ-lactone
CAS Number
6850-30-2
Synonyms
  • 4-Dehydrowithaferin A
Molecular Formula
C28H36O6
Formula Weight
468.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMSO: 5mg/mLDMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
λmax
225 nm
SMILES
O=C(C=C1)[C@@]2(C)[C@@]([C@H]3C[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@]5([H])[C@H](C)[C@@]6([H])CC(C)=C(CO)C(O6)=O)(O3)C1=O
InChi Code
InChI=1S/C28H36O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,24,29H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,24+,26+,27-,28+/m0/s1
InChi Key
XGPALHIQWWGRFB-TTWUVOALSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $96

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    5 mg

    $335

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    10 mg

    $526

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    Product Description

    4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A (Item No. 11352) that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 µM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).