A GABA-T inhibitor
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Aminooxyacetic Acid (hydrochloride)

Item No. 28298

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(aminooxy)-acetic acid, hemihydrochloride
CAS Number
2921-14-4
Synonyms
  • Aminooxyacetate
Molecular Formula
C2H5NO3 • 1/2HCl
Formula Weight
109.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2mg/mLDMSO: 5mg/mLPBS (pH 7.2): 5mg/mL
SMILES
OC(CON)=O.OC(CON)=O.Cl
InChi Code
InChI=1S/2C2H5NO3.ClH/c2*3-6-1-2(4)5;/h2*1,3H2,(H,4,5);1H
InChi Key
KBXIJIPYZKPDRU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $41

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    500 mg

    $65

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    1 g

    $96

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    Product Description

    Aminooxyacetic acid is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain.1 It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE; IC50s = 8.5 and 1.1 μM, respectively).2 Aminooxyacetic acid (100 mg/kg) decreases GABA-T activity, without affecting glutamic acid decarboxylase (GAD) activity, and increases GABA levels in all regions of rat brain.3 It also decreases GABA-T activity and increases GABA in mouse brain when administered at a dose of 13 mg/kg.4 Aminooxyacetic acid inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED50s = 53, 130, and 85 mg/kg, respectively), however, it exhibits neurotoxicity in the chimney test (ED50 = 62 mg/kg) and is lethal (LD50 = 105 mg/kg) to mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wallach, D.P. Studies on the GABA pathway. I. The inhibition of γ-aminobutyric acid-α-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid). Biochem. Pharmacol. 5(4), 323-331 (1961).

    2. Asimakopoulou, A., Panopoulos, P., Chasapis, C.T., et al. Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE). Br. J. Pharmacol. 169(4), 922-932 (2013).

    3. Löscher, W., Hönack, D., and Gramer, M. Use of inhibitors of gamma-aminobutyric acid (GABA) transaminase for the estimation of GABA turnover in various brain regions of rats: A reevaluation of aminooxyacetic acid. J. Neurochem. 53(6), 1737-1750 (1989).

    4. Löscher, W. A comparative study of the pharmacology of inhibitors of GABA-metabolism. Naunyn Schmiedebergs Arch. Pharmacol. 315(2), 119-128 (1980).