A class III antiarrhythmic agent
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Azimilide (hydrochloride)

Item No. 28300

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione, dihydrochloride
CAS Number
149888-94-8
Synonyms
  • NE 10064
Molecular Formula
C23H28ClN5O3 • 2HCl
Formula Weight
530.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
233, 257, 343 nm
SMILES
ClC1=CC=C(C2=CC=C(/C=N/N3C(N(CCCCN4CCN(C)CC4)C(C3)=O)=O)O2)C=C1.Cl.Cl
InChi Code
InChI=1S/C23H28ClN5O3.2ClH/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18;;/h4-9,16H,2-3,10-15,17H2,1H3;2*1H/b25-16+;;
InChi Key
HHPSICLSNHCSNZ-BYEGLACWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $98

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    50 mg

    $435

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    100 mg

    $819

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    Product Description

    Azimilide is a class III antiarrhythmic agent.1 It blocks rapidly activating delayed rectifier (IKr) and slowly activating delayed rectifier (IKs) potassium currents in isolated guinea pig ventricular myocytes (IC50s = 0.3 and 3 μM, respectively). Azimilide (0.1-10 μM) prolongs action potential duration (APD) in isolated calf Purkinje fibers and ventricular trabeculae in a concentration-dependent manner. It increases the effective refractory period (ERP) in isolated perfused guinea pig hearts and ferret papillary muscles. Azimilide (0.3-30 mg/kg) increases ERP and the absolute refractory period and decreases heart rate in dogs. It reduces mean arrhythmia score in a rat model of coronary artery ligation and reperfusion-induced severe ventricular arrhythmia. Azimilide (10-30 mg/kg) also prevents sustained and non-sustained ventricular tachyarrhythmias in dogs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salata, J.J., and Brooks, R.R. Pharmacology of azimilide dihydrochloride (NE‐10064), a class III antiarrhythmic agent. Cardiovasc. Drug Rev. 15(2), 137-156 (2007).