A fluorescent analog of 2'3'-cGAMP
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ε-2'3'-cGAMP (sodium salt)

Item No. 28321

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,1-(1,2-ethenediyl)adenylyl-(3'→5')-2'-guanylic acid, cyclic nucleotide, disodium salt
Molecular Formula
C22H22N10O13P2 • 2Na
Formula Weight
742.4
Purity
≥95%
Emission
408 nm
Excitation
300 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
O=P1([O-])O[C@]([C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O4)([H])[C@@]4([H])COP(O[C@@]5([H])[C@H](N6C=NC7=C6NC(N)=NC7=O)O[C@]([C@H]5O)([H])CO1)([O-])=O.[Na+].[Na+]
InChi Code
InChI=1S/C20H24N10O13P2.2Na/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33;;/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33);;/q;2*+1/p-2/t6-,7-,10-,11-,12-,13-,18-,19-;;/m1../s1
InChi Key
CNVCOPPPOWRJAV-DQNSRKNCSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    70 µg

    $468

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    Product Description

    ε-2’3’-cGAMP is a fluorescent derivative of the second messenger 2’3’-cGAMP (Item No. 19887). It has activity in an interferon-stimulated genes (ISG) reporter assay using THP-1 cells (EC50 = ≤100 nM).1 ε-2'3'-cGAMP displays excitation/emission maxima of 300/408 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, B., Sun, L., Wei, Q., et al. Cyclic di-nucleotide compounds and methods of use. (2017).