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Lasmiditan

Item No. 28369

Restricted Product (Schedule V)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • COL-144
  • LY573144
Technical Information
Formal Name
2,4,6-trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl]-benzamide
CAS Number
439239-90-4
Molecular Formula
C19H18F3N3O2
Formula Weight
377.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/ml
λmax
225, 256, 296 nm
SMILES
O=C(NC1=NC(C(C2CCN(C)CC2)=O)=CC=C1)C3=C(F)C=C(F)C=C3F
InChi Code
InChI=1S/C19H18F3N3O2/c1-25-7-5-11(6-8-25)18(26)15-3-2-4-16(23-15)24-19(27)17-13(21)9-12(20)10-14(17)22/h2-4,9-11H,5-8H2,1H3,(H,23,24,27)
InChi Key
XEDHVZKDSYZQBF-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
V
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Lasmiditan (Item No. 28369) is an analytical reference standard categorized as an agonist of the serotonin (5-HT) receptor subtype 5-HT1F.1 Formulations containing lasmiditan have been used in the treatment of migraine headache. Lasmiditan has low abuse potential.2 Lasmiditan is regulated as a Schedule V compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nelson, D.L., Phebus, L.A., Johnson, K.W., et al. Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan. Cephalalgia 30(10), 1159-1169 (2010).

    2. Wilbraham, D., Berg, P.H., Tsai, M., et al. Abuse potential of lasmiditan: A phase 1 randomized, placebo- and alprazolam-controlled crossover study. J. Clin. Pharmacol. (2019).