An inhibitor of Kv1.3 channels
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Psora 4

Item No. 28389

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-phenylbutoxy)-7H-furo[3,2-g ][1]benzopyran-7-one
CAS Number
724709-68-6
Molecular Formula
C21H18O4
Formula Weight
334.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10mg/mL
λmax
217, 251, 269, 310 nm
SMILES
O=C1C=CC2=C(OCCCCC3=CC=CC=C3)C4=C(OC=C4)C=C2O1
InChi Code
InChI=1S/C21H18O4/c22-20-10-9-16-19(25-20)14-18-17(11-13-23-18)21(16)24-12-5-4-8-15-6-2-1-3-7-15/h1-3,6-7,9-11,13-14H,4-5,8,12H2
InChi Key
JJAWGNIQEOFURP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $253

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    25 mg

    $587

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    Product Description

    Psora 4 is an inhibitor of voltage-gated potassium channels (Kv1.3; EC50 = 3 nM).1 It is selective for Kv1.3 over Kv1.1, Kv1.2, Kv1.4, Kv1.7, and Kv3.1 channels (EC50s = 62, 49, 202, 100, and 1,500 nM, respectively) but does inhibit the Kv1.5 channel (EC50 = 7.7 nM). Psora 4 selectively binds to the C-type inactivated state of the Kv1.3 channel and inhibits potassium current in a use-dependent manner. It has immunosuppressive activity, inhibiting proliferation of human and rat myelin-specific effector memory T cells in vitro (TEM cells; EC50s = 25 and 60 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vennekamp, J., Wulff, H., Beeton, C., et al. Kv1.3-blocking 5-phenylalkoxypsoralens: A new class of immunomodulators. Mol. Pharmacol. 65(6), 1364-1374 (2004).