An esterified form of α-ketoglutarate
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Dimethyl 2-ketoglutarate

Item No. 28394

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-oxo-pentanedioic acid, 1,5-dimethyl ester
CAS Number
13192-04-6
Molecular Formula
C7H10O5
Formula Weight
174.2
Purity
≥90%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
COC(CCC(C(OC)=O)=O)=O
InChi Code
InChI=1S/C7H10O5/c1-11-6(9)4-3-5(8)7(10)12-2/h3-4H2,1-2H3
InChi Key
TXIXSLPEABAEHP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 mg

    $36

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    1 g

    $49

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    5 g

    $120

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    Product Description

    Dimethyl 2-ketoglutarate is an esterified form of the citric acid cycle intermediate α-ketoglutarate.1 It increases intracellular levels of α-ketoglutarate and decreases intracellular ATP levels in U2OS human osteosarcoma cells cultured in complete- or nutrient-free media when used at a concentration of 5 mM.2 Dimethyl 2-ketoglutarate inhibits autophagy and decreases in intracellular levels of acetyl-CoA in serum- and nutrient-deprived cells.3 It decreases cardiomyocyte hypertrophy in a mouse model of cardiac pressure overload induced by thoracic aortic constriction when administered at a dose of 300 mg/kg. Dimethyl 2-ketoglutarate reduces serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and hepatic fibrosis in a rat model of liver fibrosis induced by carbon tetrachloride (CCl4).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, J., Peng, L., Cui, R., et al. Dimethyl α-ketoglutarate reduces CCl4-induced liver fibrosis through inhibition of autophagy in hepatic stellate cells. Biochem. Biophys. Res. Commun. 481(1-2), 90-96 (2021).

    2. Baracco, E.E., Castoldi, F., Durand, S., et al. α-Ketoglutarate inhibits autophagy. Aging (Albany NY) 11(11), 3418-3431 (2021).

    3. Mariño, G., Pietrocola, F., Eisenberg, T., et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol. Cell 53(5), 710-725 (2014).

    Product Citations

    Greene, K.S., Choi, A., Yang, N., et al. Glutamine metabolism is essential for coronavirus replication in host cells and in mice. The Journal of Biological Chemisty 301(1), 108063 (2025).