An arginase inhibitor
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Arginase Inhibitor 1

Item No. 28418

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR)-α-amino-α-(4-boronobutyl)-1-piperidinebutanoic acid
CAS Number
1345808-25-4
Molecular Formula
C13H27BN2O4
Formula Weight
286.2
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/mlWater: 30 mg/ml
SMILES
OB(O)CCCC[C@@](C(O)=O)(N)CCN1CCCCC1
InChi Code
InChI=1S/C13H27BN2O4/c15-13(12(17)18,6-2-3-8-14(19)20)7-11-16-9-4-1-5-10-16/h19-20H,1-11,15H2,(H,17,18)/t13-/m1/s1
InChi Key
CHPILBYRQPOXMV-CYBMUJFWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $169

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    5 mg

    $753

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    Product Description

    Arginase inhibitor 1 is an inhibitor of arginase I and II (IC50s = 223 and 509 nM, respectively, for the recombinant human enzymes).1 It decreases arginase I activity in CHOK cells expressing human arginase I (IC50 = 8 µM). Arginase inhibitor 1 (100 mg/kg, i.v.) reduces infarct size in a rat model of myocardial ischemia and reperfusion injury induced by left-main coronary artery occlusion.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Van Zandt, M.C., Whitehouse, D.L., Golebiowski, A., et al. Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J. Med. Chem. 56(6), 2568-2580 (2013).