A RORɣ agonist
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Cintirorgon

Item No. 28425

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-6-[3-(difluoromethoxy)-5-fluorophenyl]-3,4-dihydro-α,α-dimethyl-4-[[3-(trifluoromethyl)phenyl]sulfonyl]-2H-1,4-benzoxazine-2-propanoic acid
CAS Number
2055536-64-4
Synonyms
  • LYC-55716
Molecular Formula
C27H23F6NO6S
Formula Weight
603.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mg/ml
λmax
214, 267 nm
SMILES
FC1=CC(OC(F)F)=CC(C(C=C2)=CC3=C2O[C@@H](CC(C)(C)C(O)=O)CN3S(C4=CC=CC(C(F)(F)F)=C4)(=O)=O)=C1
InChi Code
InChI=1S/C27H23F6NO6S/c1-26(2,24(35)36)13-20-14-34(41(37,38)21-5-3-4-17(11-21)27(31,32)33)22-10-15(6-7-23(22)39-20)16-8-18(28)12-19(9-16)40-25(29)30/h3-12,20,25H,13-14H2,1-2H3,(H,35,36)/t20-/m0/s1
InChi Key
GULSIMHVQYBADX-FQEVSTJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $72

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    5 mg

    $197

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    10 mg

    $286

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    25 mg

    $626

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    Product Description

    Cintirorgon is a retinoic acid receptor-related orphan receptor ɣ (RORɣ) agonist with EC50 values of less than 0.5 µM in a reporter assay and time-resolved FRET (TR-FRET) assay.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aicher, T.D., Taylor, C.B., and Vanhuis, C.A. Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease. (2016).