An A1 adenosine receptor agonist
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N6-Cyclohexyladenosine

Item No. 28427

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-cyclohexyl-adenosine
CAS Number
36396-99-3
Molecular Formula
C16H23N5O4
Formula Weight
349.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20mg/mLDMF:PBS (pH 7.2) (1:1): 0.5mg/mLDMSO: 5mg/mLDMSO:PBS (pH 7.2) (1:6): 0.14mg/mLEthanol: 3mg/mL
λmax
212, 269 nm
SMILES
[H][C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)N2C=NC3=C(NC4CCCCC4)N=CN=C32
InChi Code
InChI=1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1
InChi Key
SZBULDQSDUXAPJ-XNIJJKJLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $69

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    50 mg

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    100 mg

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    Product Description

    N6-Cyclohexyladenosine is an adenosine receptor agonist.1 It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively).1 N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion.2 N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hutchison, A.J., Webb, R.L., Oei, H.H., et al. CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. J. Pharmacol. Exp. Ther. 251(1), 47-55 (1989).

    2. Blanco-Centurion, C., Xu, M., Murillo-Rodriguez, E., et al. Adenosine and sleep homeostasis in the basal forebrain. J Neurosci. 26(31), 8092-8100 (2006).

    3. Nikodijević, O., Daly, J.W., and Jacobson, K.A. Characterization of the locomotor depression produced by an A2-selective adenosine agonist. FEBS Lett. 261(1), 67-70 (1990).