An inhibitor of IDO1
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Product Categories

Product Type

Small Molecule Modulators
Small Molecule Inhibitors

Research Area

IDO-IN-3

Item No. 28432

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(2-aminoethyl)amino]-N′-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide
CAS Number
2070018-30-1
Molecular Formula
C11H12BrFN6O2
Formula Weight
359.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/ml
λmax
211, 290 nm
SMILES
BrC1=C(F)C=CC(/N=C(C2=NON=C2NCCN)/NO)=C1
InChi Code
InChI=1S/C11H12BrFN6O2/c12-7-5-6(1-2-8(7)13)16-11(17-20)9-10(15-4-3-14)19-21-18-9/h1-2,5,20H,3-4,14H2,(H,15,19)(H,16,17)
InChi Key
DAPNMIADTFAXEG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $327

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    Product Description

    IDO-IN-3 is an inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1; IC50s = 290 and 98 nM for the human recombinant enzyme in a cell-free assay and in HeLa cells, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yue, E.W., Sparks, R.B., Polam, P., et al. INCB24360 (epacadostat), a highly potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor for immuno-oncology. Med. Chem. Lett. 8(5), 486-491 (2017).