An immunomodulator
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Paquinimod

Item No. 28443

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,5-diethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide
CAS Number
248282-01-1
Synonyms
  • ABR-25757
Molecular Formula
C21H22N2O3
Formula Weight
350.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20mg/mLDMF:PBS (pH 7.2) (1:5): 0.16mg/mLDMSO: 15mg/mLEthanol: 3mg/mL
λmax
233, 298 nm
SMILES
CCC1=C2C(N(C)C(C(C(N(CC)C3=CC=CC=C3)=O)=C2O)=O)=CC=C1
InChi Code
InChI=1S/C21H22N2O3/c1-4-14-10-9-13-16-17(14)19(24)18(20(25)22(16)3)21(26)23(5-2)15-11-7-6-8-12-15/h6-13,24H,4-5H2,1-3H3
InChi Key
DIKSYHCCYVYKRO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $61

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    5 mg

    $247

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    10 mg

    $462

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    25 mg

    $1,006

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    Product Description

    Paquinimod is an immunomodulator.1,2,3,4 In vivo, paquinimod reduces splenic counts of Ly6ChiCD115+ inflammatory monocytes and CD11b+CD11c+ dendritic cells in a mouse model of experimental autoimmune encephalomyelitis (EAE).1 Paquinimod (25 mg/kg per day) reduces hepatic fibrosis and accumulation of inflammatory monocytes and neutrophils in the N-IF mouse model of liver fibrosis.2 It delays disease onset and decreases insulitis in non-obese diabetic (NOD) mice.3 Paquinimod (5 and 25 mg/kg) reduces skin thickness, the number of myofibroblasts, and autoantibody production in the tight skin 1 mouse model of systemic sclerosis.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Helmersson, S., Sundstedt, A., Deronic, A., et al. Amelioration of experimental autoimmune encephalomyelitis by the quinoline-3-carboxamide paquinimod: Reduced priming of proinflammatory effector CD4+ T cells. Am. J. Pathol. 182(5), 1671-1680 (2013).

    2. Fransén Pettersson, N., Deronic, A., Hannibal, T.D., et al. The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosis. PLoS One 13(9), e0203228 (2018).

    3. Tahvili, S., Törngren, M., Holmberg, D., et al. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse. PLoS One 13(5), e0196598 (2018).

    4. Stenström, M., Nyhlén, H.C., Törngren, M., et al. Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis. J. Dermatol. Sci. 83(1), 52-59 (2016).