An adenosine receptor agonist
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PD 117519

Item No. 28444

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1R)-2,3-dihydro-1H-inden-1-yl]-adenosine
CAS Number
96392-15-3
Synonyms
  • CI-947
Molecular Formula
C19H21N5O4
Formula Weight
383.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMF:PBS (pH 7.2) (1:4): 0.2mg/mLDMSO: 5mg/mLEthanol: 0.1mg/mL
λmax
211, 273 nm
SMILES
OC[C@H]([C@@H](O)[C@H]1O)O[C@@]1([H])N2C=NC3=C(N[C@@H]4CCC5=C4C=CC=C5)N=CN=C32
InChi Code
InChI=1S/C19H21N5O4/c25-7-13-15(26)16(27)19(28-13)24-9-22-14-17(20-8-21-18(14)24)23-12-6-5-10-3-1-2-4-11(10)12/h1-4,8-9,12-13,15-16,19,25-27H,5-7H2,(H,20,21,23)/t12-,13-,15-,16-,19-/m1/s1
InChi Key
FSKMJUWPFLDDRS-BYMDKACISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $110

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    25 mg

    $229

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    50 mg

    $423

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    Product Description

    PD 117519 is an adenosine receptor agonist.1 It selectively binds to adenosine A2 receptors (IC50 = 30 µM) over A1 receptors (IC50 = 810 µM) in rat brain membranes. PD 117519 increases heart rate and decreases systolic blood pressure in normotensive dogs when administered at doses of 2 or 10 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Steffen, R.P. Method of treating heart failure and medicaments therefor. (1987).

    2. Enerson, B.E., Lin, A., Lu, B., et al. Acute drug-induced vascular injury in beagle dogs: Pathology and correlating genomic expression. Toxicol. Pathol. 34(1), 27-32 (2006).