An inhibitor of CD73
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PSB-12379

Item No. 28446

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(phenylmethyl)-adenosine, 5′-[hydrogen P-(phosphonomethyl)phosphonate]
CAS Number
1802226-78-3
Molecular Formula
C18H23N5O9P2
Formula Weight
515.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mLWater: 5 mg/ml, sonicatedWater: Slightly soluble: 0.1-1 mg/mL
SMILES
O=P(CP(O)(O)=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@]([H])(N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C32)O1
InChi Code
InChI=1S/C18H23N5O9P2/c24-14-12(7-31-34(29,30)10-33(26,27)28)32-18(15(14)25)23-9-22-13-16(20-8-21-17(13)23)19-6-11-4-2-1-3-5-11/h1-5,8-9,12,14-15,18,24-25H,6-7,10H2,(H,29,30)(H,19,20,21)(H2,26,27,28)/t12-,14-,15-,18-/m1/s1
InChi Key
DMBYYIJBPDWQFF-SCFUHWHPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $257

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    10 mg

    $363

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    Product Description

    PSB-12379 is an inhibitor of ecto-5’-nucleotidase (CD73; Kis = 2.21 and 9.03 nM for the recombinant human and rat enzyme, respectively).1 It is selective for CD73 over human nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1), -2, and -3, ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), -2, and -3 (Kis = >10,000 nM for all), as well as the purinergic P2Y1 and P2Y12 receptors at 10 µM. PSB-12379 inhibits CD73 in isolated human serum with a Ki value of 18.8 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhattarai, S., Freundlieb, M., Pippel, J., et al. α,β-Methylene-ADP (AOPCP) derivatives and analogues: Development of potent and selective ecto-5′-nucleotidase (CD73) inhibitors. J. Med. Chem. 58, 6248-6263 (2015).