An adenosine A1 receptor agonist
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Tecadenoson

Item No. 28449

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3R)-tetrahydro-3-furanyl]-adenosine
CAS Number
204512-90-3
Synonyms
  • CVT-510
Molecular Formula
C14H19N5O5
Formula Weight
337.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: Partially solublePBS (pH 7.2): 3 mg/ml
λmax
213, 268 nm
SMILES
OC[C@H]([C@@H](O)[C@H]1O)O[C@@]1([H])N2C=NC3=C(N[C@@H]4CCOC4)N=CN=C32
InChi Code
InChI=1S/C14H19N5O5/c20-3-8-10(21)11(22)14(24-8)19-6-17-9-12(15-5-16-13(9)19)18-7-1-2-23-4-7/h5-8,10-11,14,20-22H,1-4H2,(H,15,16,18)/t7-,8-,10-,11-,14-/m1/s1
InChi Key
OESBDSFYJMDRJY-BAYCTPFLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $90

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    250 mg

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    500 mg

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    1 g

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    Product Description

    Tecadenoson is an adenosine A1 receptor agonist (Ki = 6.5 nM).1 It is selective for adenosine A1 over A2 receptors (Ki = 2,315 nM). Tecadenoson prolongs stimulus-His bundle potential (SH) intervals in isolated perfused guinea pig hearts (EC50 = 40.6 nM). In vivo, tecadenoson induces PR interval prolongation in anesthetized guinea pigs (ED50 = 0.9 μg/kg) and reduces heart rate in anesthetized rats in a dose-dependent manner, without affecting blood pressure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheung, J.W., and Lerman, B.B. CVT-510: A selective A1 adenosine receptor agonist. Cardiovasc. Drug Rev. 21(4), 277-292 (2003).