A fungal metabolite
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Cerevisterol

Item No. 28466

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,5α,6β,22E)-ergosta-7,22-diene-3,5,6-triol
CAS Number
516-37-0
Molecular Formula
C28H46O3
Formula Weight
430.7
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: solubleMethanol: soluble
SMILES
C[C@H](/C=C/[C@H](C)C(C)C)[C@@]1([H])CC[C@@]2([H])C3=C[C@@H](O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C28H46O3/c1-17(2)18(3)7-8-19(4)22-9-10-23-21-15-25(30)28(31)16-20(29)11-14-27(28,6)24(21)12-13-26(22,23)5/h7-8,15,17-20,22-25,29-31H,9-14,16H2,1-6H3/b8-7+/t18-,19+,20-,22+,23-,24-,25+,26+,27+,28-/m0/s1
InChi Key
ARXHRTZAVQOQEU-BRVLHLJYSA-N
Origin
Fungus/Trichoderma sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $534

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    Product Description

    Cerevisterol is an ergosterol fungal metabolite originally isolated from S. cerevisiae that has diverse biological activities, including antimicrobial, anti-inflammatory, and anticancer properties.1 It is active against the bacteria S. typhi, S. aureus, and E. faecalis (MICs = 25, 25, and 50 µg/ml, respectively) and the fungus A. niger (MIC = 25 µg/ml), but has no effect on the bacteria E. coli, P. aeruginosa, S. pyogenes, K. pneumoniae, and B. subtilis, or the fungi C. albicans, A. flavus, and A. tamarii when used at concentrations up to 400 µg/ml.2 Cerevisterol (2-20 µM) inhibits LPS-induced increases in the levels of nitric oxide (NO), TNF-α, IL-6, IL-10, and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells.3 It inhibits proliferation of MCF-7, MDA-MB-231, and Caco-2 cancer cells (EC50s = 64.5, 52.4, and 37.6 µM, respectively), but not PC3, PANC-1, or A549 cells (IC50 = >100 µM for all).4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bills, C.E., and Honeywell, E.M. Antiricketic substances: VIII. Studies on highly purified ergosterol and its esters. The Journal of Biological Chemisty 80, 15-23 (1928).

    2. Appiah, T., Agyare, C., Luo, Y., et al. Antimicrobial and resistance modifying activities of cerevisterol isolated from Trametes species. Curr. Bioact. Compd. 14, (2018).

    3. Liu, Y.-W., Mei, H.-C., Su, Y.-W., et al. Inhibitory effects of Pleurotus tuber-regium mycelia and bioactive constituents on LPS-treated RAW 264.7 cells. J. Funct. Foods 7, 662-670 (2014).

    4. Wang, H., Liu, T., and Xin, Z. A new glucitol from an endophytic fungus Fusarium equiseti Salicorn 8. Eur. Food Res. Technol. 239(3), 365-376 (2014).

    5. Wang, Q.-X., Li, S.-F., Zhao, F., et al. Chemical constituents from endophytic fungus Fusarium oxysporum. Fitoterapia 82(5), 777-781 (2011).