An internal standard for the quantification of pantoprazole
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Unlabeled Version(s)
21345Pantoprazole
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Pantoprazole-d6

Item No. 28483

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(difluoromethoxy)-2-[[[3,4-di(methoxy-d3)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
CAS Number
922727-65-9
Molecular Formula
C16H9D6F2N3O4S
Formula Weight
389.4
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=S(CC(N=CC=C1OC([2H])([2H])[2H])=C1OC([2H])([2H])[2H])C2=NC3=CC(OC(F)F)=CC=C3N2
InChi Code
InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)/i1D3,2D3
InChi Key
IQPSEEYGBUAQFF-WFGJKAKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $534

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    Product Description

    Pantoprazole-d6 is intended for use as an internal standard for the quantification of pantoprazole (Item No. 21345) by GC- or LC-MS. Pantoprazole is a proton pump inhibitor that inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles with an IC50 value of 6.8 µM.1 It reduces basal gastric acid secretion in pylorus-ligated rats (ED50 = 1.3 mg/kg) and inhibits mepirizole-induced increases in gastric acid secretion in an anesthetized rat model of gastric fistula (ED50 = 0.8 mg/kg).2 Pantoprazole inhibits formation of mepirizole-induced duodenal lesions in rats (ED50 = 0.5 mg/kg). Formulations containing pantoprazole have been used in the treatment of gastroesophageal reflux disease (GERD) and hypersecretory conditions, including Zollinger-Ellison Syndrome.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beil, W., Staar, U., and Sewing, K.F. Pantoprazole: A novel H+/K+-ATPase inhibitor with an improved pH stability. Eur. J. Pharmacol. 218(2-3), 265-271 (1992).

    2. Takeuchi, K., Konaka, A., Nishijima, M., et al. Effects of pantoprazole, a novel H+/K+-ATPase inhibitor, on duodenal ulcerogenic and healing responses in rats: A comparative study with omeprazole and lansoprazole. J. Gastroenterol. Hepatol. 14(3), 251-257 (1999).