An iron chelator
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Product Categories

Product Type

Biochemicals
Metal Chelators

SP-420

Item No. 28498

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S)-4,5-dihydro-2-[2-hydroxy-4-[2-(2-methoxyethoxy)ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid
CAS Number
911714-45-9
Synonyms
  • (S)-4′-(HO)-DADFT-norPE
Molecular Formula
C16H21NO6S
Formula Weight
355.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 15 mg/mlEthanol: 15 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
214, 273, 309 nm
SMILES
OC1=CC(OCCOCCOC)=CC=C1C2=N[C@](C(O)=O)(C)CS2
InChi Code
InChI=1S/C16H21NO6S/c1-16(15(19)20)10-24-14(17-16)12-4-3-11(9-13(12)18)23-8-7-22-6-5-21-2/h3-4,9,18H,5-8,10H2,1-2H3,(H,19,20)/t16-/m1/s1
InChi Key
YASYAEVZKXPYIZ-MRXNPFEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    25 mg

    $502

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    Product Description

    SP-420 is an iron chelator and a derivative of desferrothiocin.1 It induces iron excretion in rat bile and urine with an iron-clearing efficiency (ICE) value of 26.7% when administered at a dose of 300 μmol/kg and decreases iron levels in rat liver and heart at 384 μmol/kg per day. SP-420 (75 μmol/kg) also induces iron excretion in iron-overloaded C. apella monkeys (ICE = 26.3%).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bergeron, R.J., Bharti, N., Wiegand, J., et al. The impact of polyether chain length on the iron clearing efficiency and physiochemical properties of desferrithiocin analogues. J. Med. Chem. 53(7), 2843-2853 (2010).