An alkaloid with mutagenic activity
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Product Type

Biochemicals
Natural Products
Alkaloids

Research Area

Aristolochic Acid B

Item No. 28504

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid
CAS Number
475-80-9
Synonyms
  • Aristolochic Acid II
Molecular Formula
C16H9NO6
Formula Weight
311.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlEthanol: SolubleWater: Slightly Soluble
λmax
217, 251, 298, 358 nm
SMILES
O=C(O)C1=CC(OCO2)=C2C3=C1C([N+]([O-])=O)=CC4=CC=CC=C43
InChi Code
InChI=1S/C16H9NO6/c18-16(19)10-6-12-15(23-7-22-12)14-9-4-2-1-3-8(9)5-11(13(10)14)17(20)21/h1-6H,7H2,(H,18,19)
InChi Key
MEEXETVZNQYRSP-UHFFFAOYSA-N
Origin
Plant/Aristolochia debilis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    Aristolochic acid B is an alkaloid that has been found in Aristolochia with mutagenic activity.1 It forms DNA adducts under anaerobic conditions in vitro when used at a concentration of 0.4 mM. Oral administration of aristolochic acid B (0.03 mmol/kg) induces bladder, forestomach, and kidney DNA adduct formation in rats. Aristolochic acid B reduces body weight and urine concentrations of sodium, potassium, and calcium, enlarges the liver and kidneys, and increases blood concentrations of hemoglobin and hematocrit in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmeiser, H.H., Schoepe, K.-B., and Wiessler, M. DNA adduct formation of aristolochic acid I and II in vitro and in vivo. Carcinogenesis 9(2), 297-303 (1988).

    2. Yeh, Y.-H., Lee, Y.-T., Hsieh, H.-S., et al. Short-term toxicity of aristolochic acid, aristolochic acid-I and aristolochic acid-II in rats. Food Chem. Toxicol. 46(3), 1157-1163 (2008).