An alkaloid with anticancer activity
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Product Categories

Product Type

Biochemicals
Natural Products
Alkaloids

Research Area

Cancer

Aristolochic Acid C

Item No. 28505

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10-hydroxy-6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid
CAS Number
4849-90-5
Synonyms
  • Aristolochic Acid IIIa
Molecular Formula
C16H9NO7
Formula Weight
327.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly, heated
SMILES
O=C(O)C1=CC(OCO2)=C2C3=C1C([N+]([O-])=O)=CC4=CC=C(O)C=C43
InChi Code
InChI=1S/C16H9NO7/c18-8-2-1-7-3-11(17(21)22)13-10(16(19)20)5-12-15(24-6-23-12)14(13)9(7)4-8/h1-5,18H,6H2,(H,19,20)
InChi Key
NBFGYDJKTHENDP-UHFFFAOYSA-N
Origin
Plant/Aristolochiaceae
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

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    5 mg

    $160

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    10 mg

    $266

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    Cayman Chemical
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    Product Description

    Aristolochic acid C is an alkaloid originally isolated from Aristolochia argentina and a derivative of aristolochic acid (Item No. 21520) that has anticancer activities.1,2,3 It inhibits the growth of LLC-PK1, P388, HT-29, and HL-60 cancer cells (IC50s = 85, 8.8, 17.1, and 40 µM, respectively).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cai, Y., and Cai, T.-G. Two new aristolochic acid derivatives from the roots of Aristolochia fangchi and their cytotoxicities. Chem. Pharm. Bull. (Tokyo) 58(8), 1093-1095 (2010).

    2. Wu, T.-S., Chan, Y.-Y., and Leu, Y.-L. The constituents of the root and stem of Aristolochia cucurbitifolia Hayata and their biological activity. Chem. Pharm. Bull. (Tokyo) 48(7), 1006-1009 (2000).

    3. Kumar, V., Poonam, Prasad, A.K., et al. Naturally occurring aristolactams, aristolochic acids and dioxoaporphines and their biological activities. Nat. Prod. Rep. 20(6), 565-583 (2003).